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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TSC2
All Species:
22.12
Human Site:
S946
Identified Species:
48.67
UniProt:
P49815
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49815
NP_000539.2
1807
200608
S946
S
L
N
E
R
P
K
S
L
R
I
A
R
P
P
Chimpanzee
Pan troglodytes
XP_523477
1803
200189
S946
S
L
N
E
R
P
K
S
L
R
I
A
R
P
P
Rhesus Macaque
Macaca mulatta
XP_001083256
1807
200600
S946
S
L
N
E
R
P
K
S
L
R
I
A
R
P
P
Dog
Lupus familis
XP_852047
1813
201226
S946
S
L
N
E
R
P
K
S
L
R
I
A
R
P
P
Cat
Felis silvestris
Mouse
Mus musculus
Q61037
1814
202053
S946
S
L
N
E
R
P
K
S
L
R
I
A
R
A
P
Rat
Rattus norvegicus
P49816
1809
201259
S946
S
L
N
E
R
P
K
S
L
R
I
A
R
A
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516748
947
107028
H122
H
L
G
I
L
R
A
H
I
F
R
V
I
K
E
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_695912
1128
123244
L303
G
L
R
S
N
A
L
L
P
F
D
D
T
H
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524177
1847
204101
G1017
P
S
A
P
A
R
S
G
L
C
E
R
C
A
Q
Honey Bee
Apis mellifera
XP_395739
1813
206229
R949
S
L
T
E
Q
G
S
R
G
R
R
E
R
P
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786931
1947
217345
V1046
R
T
E
D
Q
E
E
V
K
H
L
T
L
F
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
97.9
91.2
N.A.
88.9
91
N.A.
44.1
N.A.
N.A.
35.8
N.A.
29.8
38.2
N.A.
31.1
Protein Similarity:
100
99
99
94.6
N.A.
92.2
93.9
N.A.
48.3
N.A.
N.A.
44.3
N.A.
49.7
58.6
N.A.
48.9
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
6.6
N.A.
N.A.
6.6
N.A.
6.6
40
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
13.3
N.A.
N.A.
6.6
N.A.
6.6
46.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
10
10
10
0
0
0
0
55
0
28
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
10
0
0
10
0
0
% C
% Asp:
0
0
0
10
0
0
0
0
0
0
10
10
0
0
0
% D
% Glu:
0
0
10
64
0
10
10
0
0
0
10
10
0
0
19
% E
% Phe:
0
0
0
0
0
0
0
0
0
19
0
0
0
10
0
% F
% Gly:
10
0
10
0
0
10
0
10
10
0
0
0
0
0
0
% G
% His:
10
0
0
0
0
0
0
10
0
10
0
0
0
10
0
% H
% Ile:
0
0
0
10
0
0
0
0
10
0
55
0
10
0
10
% I
% Lys:
0
0
0
0
0
0
55
0
10
0
0
0
0
10
0
% K
% Leu:
0
82
0
0
10
0
10
10
64
0
10
0
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
55
0
10
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
10
0
0
10
0
55
0
0
10
0
0
0
0
46
55
% P
% Gln:
0
0
0
0
19
0
0
0
0
0
0
0
0
0
10
% Q
% Arg:
10
0
10
0
55
19
0
10
0
64
19
10
64
0
0
% R
% Ser:
64
10
0
10
0
0
19
55
0
0
0
0
0
0
10
% S
% Thr:
0
10
10
0
0
0
0
0
0
0
0
10
10
0
0
% T
% Val:
0
0
0
0
0
0
0
10
0
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _